Influenza neuraminidase

Influenza neuraminidase

Influenza neuraminidase is the target of two licensed antivirals that have been very successful, with several more in development. However, neuraminidase has been largely ignored as a vaccine target despite evidence that inclusion of neuraminidase in the subunit vaccine gives increased protection. This article describes current knowledge on the structure, enzyme activity, and antigenic signific...

Neuraminidase inhibitors for influenza.

N Engl J Med 2005;353:1363-73. Copyright © 2005 Massachusetts Medical Society. he impact of influenza infection is felt globally each year when the disease develops in approximately 20 percent of the world’s population. In the United States, influenza infections occur in epidemics each winter, generally between late December and early March. Recent events, including human cases of avian influen...

Influenza virus neuraminidase.

Antiserum specific for influenza A2 neuraminidase was produced by immunization of rabbits with the purified enzyme which had been isolated by electrophoresis from the proteins of a detergent-disrupted AoA2 influenza virus recombinant [X-7 (Fl)]. This recombinant contained hemagglutinin of the Ao subtype and A2 neuraminidase. Antiserum to the isolated A2 neuraminidase did not react in any of fou...

Antibody response in man to influenza virus neuraminidase following influenza.

Genetic recombination of influenza viruses of different subtype may result in segregation of hemagglutinin and neuraminidase in antigenically hybrid viruses [E. D. Kilbourne et al., in M. Pollard (ed.), Perspectives in Virology, vol. 5, p. 87, Academic Press, Inc., N.Y., 1967; and W. G. Laver and E. D. Kilbourne, Virology 30:493, 1966]. The selective use of such antigenic hybrids in serological...

Replication-Competent Neuraminidase-Negative Influenza H5N1 Viruses